Uncover the mechanisms of Alzheimer’s disease from multi-omics atlas
Alzheimer’s disease (AD), the leading cause of dementia in the elderly, is a progressive and fatal neurodegenerative disease that affects 40-50 million people worldwide1. Pathologically, AD is characterized by intracellular hyperphosphorylated tau aggregates and extracellular-amyloid plaques, which coincide with the activation of innate immunity, gliosis induced by activated microglia and reactive astrocytes, white matter degeneration, [...]