Inferring cell-to-cell communications in tumor ecosystems from multi- omics data
Cell-to-cell communication reveals a dynamic cellular ecosystem that develops, evolves, and responds to environmental factors. The role of cell-to-cell communication has been extensively investigated, particularly in cancer. Breakthroughs arising from discoveries in cell-to-cell communication have led to important clinical applications in cancer therapy. Most existing ligand-receptor interaction studies only utilize single-modal omics data, which only [...]